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Description

By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

Individuals with appetite control challenges in particular may prefer Contrave over Ozempic

Pollock PM, Harper UL, Hansen KS, et al

The FDA warning letter from February 20, 2026 cited misleading marketing language, not an unsafe product, but it is a documented compliance issue patients should factor into their decision